Kishanta Kumar Pradhan,Ranganadha Rao K,P. Srinivasulu's Analytical Method Development and Stability Studies of PDF

By Kishanta Kumar Pradhan,Ranganadha Rao K,P. Srinivasulu

Master's Thesis from the yr 2011 within the topic medication - Pharmacology, grade: 8.0, , direction: B.Pharm.,M.Pharm, language: English, summary: A opposite part excessive functionality liquid chromatographic procedure (HPLC) has been constructed for the tactic improvement validation of Carvedilol in bulk and pharmaceutical formula through the use of YMC PACK professional 4.6 X one hundred fifty mm (5µm Particle size). The cellular part was once Buffer: Acetonitrile: (70:30) and pH was once adjusted to two pumped at a circulation expense of one ml/min and the eluents have been monitored at 320nm. Linearity used to be acquired within the focus diversity of 10-90 μg/ml. The retention time of Carvedilol was once came across to be 3.2 minute. the strategy was once verified for specificity, accuracy, precision, linearity, and restrict of detection, restrict of quantification, robustness and solubility balance. LOD and LOQ have been came upon to be 0.001 μg/ml and 0.011μg/ml respectively. the tactic used to be statistically established and RSD was once came upon to be below 2% indicating excessive measure of accuracy and precision of the proposed HPLC strategy. balance research record printed that the drug is weak for acidic, alkaline, oxidative, photolytic and UV degradation. The drug is solid to thermal degradation. extra over the degradants have been good separated from its API. because of its simplicity, rapidness, excessive precision and accuracy, the proposed HPLC strategy can be utilized for opting for Carvedilol in bulk drug samples or in pharmaceutical dosage forms.

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Analytical Method Development and Stability Studies of Carvedilol by Kishanta Kumar Pradhan,Ranganadha Rao K,P. Srinivasulu


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